Piccolo used this attack during his battle against Cell in his Imperfect form. After being knocked down by Cell, Piccolo charged up and fired the Light Grenade against the approaching Cell, creating a huge explosion. While it did blast Cell into the ocean, the Android emerged completely unscathed, much to Piccolo's shock. Much later Chris uses this attack for the first time against Steve during there first battle which destroyed half of the island they were fighting on and inlicted a massive amount of damage to him but he survived and countered with the Meteor Combination.
Light Grenalde appeared in the Budokai and Budokai Tenkaichi series, where it is one of Piccolo (End)'s Blast 2 attacks. It reappeared in Dragon Ball: Raging Blast and Dragon Ball: Raging Blast 2, but it was changed to his Ultimate Attack; in these games, when someone is hit by this attack, it changes from a energy ball to a large energy blast like it was in the original series.